Address: Stroke Research Centre, UCL Institute of Neurology

10-12 Russell Square

London WC1B 5EH

Telephone: 020 3108 7493 (office)

Email: d.werring@.ucl.ac.uk

GMC Number: 3663381

CURRENT POST

October 2015- Professor of Clinical Neurology (Personal Chair)

Honorary Consultant Neurologist. UCL Institute of Neurology, Queen Square; and National Hospital for Neurology and Neurosurgery, University College Hospitals NHS Foundation Trust

2008-2015 Reader in Clinical Neurology and Honorary Consultant Neurologist

EDUCATION AND QUALIFICATIONS

1986-1992 MBBS and BSc (Hons) Neurosciences (Guy’s Hospital Medical School)

February 1995 MRCP (UK)

December 2000 PhD Clinical Neurology (University College London)

2002-2003 Stroke Association Clinical Training Fellowship

May 2004 CCST Neurology

June 2012 FRCP

PRIZES AND PEER ESTEEM INDICATORS

2018 Chair-Elect UK Stroke Forum (2019-2021)

2018 Member, Editorial Board, Practical Neurology

2018 Chair, Association of British Neurologists Stroke Advisory Group

2018 Member (neurologist), NICE Stroke Guideline (update) Committee 2018

2017 Head of Research Department of Brain Repair and Rehabilitation, UCL Institute of Neurology

2017 Member, CHEST (American College of Chest Physicians) Atrial Fibrillation Guideline Panel

2017 Member, European Stroke Association Atrial Fibrillation Guideline Committee

2016 Member, Editorial Board, European Stroke Journal

2016 Member, Board of Directors, European Stroke Organisation

2016 Member, Steering Group, UCL Neurosciences Domain

2016 Honorary Assistant Secretary, British Association of Stroke Physicians

2015 Course Director, MSc. Stroke Medicine, UCL

2015 Member, UK Intercollegiate Guidelines Working Group for Stroke

2015 Chair, European Stroke Organisation Educational Committee

2014 Expert member, MHRA Commission on Human Medicines Expert Working Group – benefits and risks of alteplase in the treatment of ischaemic stroke

2014 Clinical Specialty Lead for Stroke, NIHR CRN: North Thames

2013 Chair, organising committee 4^th International Cerebral Amyloid Angiopathy (CAA) Conference

2012 Member, abstract scientific committee, International Stroke Conference

2011 Elected Fellow European Stroke Organization

2011 Member of Stroke Prevention Studies Group, NIHR Stroke Research Network

2010 Member, European Stroke Conference Scientific Committee

EXPERIENCE IN RESEARCH

• Experienced CI for large NIHR multicenter trials including CROMIS-2 (Clinical Relevance of Microbleeds in Stroke; www.ucl.ac.uk/cromis-2); recruited > 2500 patients at 75 UK hospitals to time and target; aims to determine neuroimaging and genetic predictors of bleeding risk during oral anticoagulation for AF with a focus on cerebral microbleeds (CMBs).

• CI for Genetics and Observational Study of Subarachnoid Haemorrhage (>2500 patients)

• CI for ongoing randomised controlled trials in Intracerebral haemorrhage (ICH): PROHIBIT-ICH and OPTIMAS

• PI, co-applicant, steering committee member for RESTART, TICH-2, LACI-2 (the largest current randomized controlled trials of ICH and small vessel disease in the UK).

• Specialty Clinical Lead (North Thames) covering stroke research for ~10 million population.

• Coordination of a research group: supervisor for PhD, MSc and postdoctoral students

EXPERIENCE IN CLINICAL STROKE CARE

• I help deliver/develop the flagship UCH Comprehensive Stroke Service (treating >2,000 suspected strokes yearly) which performs in the top quartile of rigorous Stroke Improvement National Audit Program and local Cardiac and Stroke Network standards; as lead for training and research I strive to ensure that research is fully integrated into all patient pathways.

• I have set up new acute clinical pathways and clinics for patients with ICH including a new one-stop multidisciplinary clinic.

• An audit of a new rapid reversal pathway for anticoagulant-related ICH recently won the Queen Square Quality Improvement Award (2017)

• I am internationally recognized as a clinical expert in cerebral small vessel disease and intracerebral haemorrhage (ICH); invited keynote speaker nationally and internationally.

SELECTED RECENT GRANT AWARDS (>£12million awarded since 2007)

2008-13 Dept of Health /HEFCE Clinical Senior Lecturer Award: £250,000

2008-13 Predicting outcome and measuring benefit from botulinum toxin in stroke. Stroke

Association project Grant: £128,000 (CI)

2008-14 Genetics of Subarachnoid Haemorrhage. Stroke Association Project Grant: £140,000, further extension for £86,000 awarded 2012 (CI)

2011-16 Stroke Association and British Heart Foundation Joint Programme Grant Microbleeds and genetic risk factors in anticoagulant related ICH: £940,000 (CI)

2011 Standards for determining the vascular contribution to neurodegeneration

Centres of Excellence in Neurodegeneration. (Co-I) (UK Partner: MRC). £54,000.

2012 Genetic and Observational Study of Subarachnoid Haemorrhage. (PI)

Stroke Association £85,575

2012 NIHR Comprehensive Local Research Network infrastructure award. (PI) £44,256

2013 NIHR Stroke Research Network Portfolio Development Grant: Effective

Prevention of Cerebral Haemorrhage (PI) £2,500

2014 Clinical Relevance of Microbleeds in Stroke (CROMIS-2). (PI) The Stroke

Association and British Heart Foundation £218,097

2014 NIHR Comprehensive Local Research Network infrastructure award. (PI) £40,509

2014 Realising the potential of cohort studies to determine the vascular contribution to neurodegeneration The EU Joint Programme – Neurodegenerative Disease Research (JPND) (Co-I) £37,500

2014 BRC strategic “Big Questions” award in stroke medicine (Co-I) £500,000

2011-14 Neuroimaging and neuropsychology in Fabry disease:£100,000.Shire pharm (co-CI)

2013-18 REstart or STop Antiplatelets Randomised Trial (RESTART) £1.34m. BHF (co-app)

2013-18 TICH-2 (Tranexamic Acid in Cerebral Haemorrhage) £2.8m. NIHR HTA (co-app)

2012-15 Imaging stroke with Electrical Impedance Tomography: £840,000. Wellcome (co-app)

2015-18 Biomarkers and Outcomes in CAA (BOCAA): £150,000. Rosetrees Trust and Leonard Wolfson Experemental Neurology Centre

2015-18 The TICH-2 MRI study. £298,962. British Heart Foundation (co-app)

2015 UCL Life Learning fund to develop Stroke MSc. Delivery £15,000 (co-app)

2016-2019 The Stroke Association Priority Programme Grant for Intracerebral Haemorrhage: £447,000. The Stroke Association

2015-18 LACunar Intervention (LACI) Trial. £847,771. British Heart Foundation (co-app)

2017 Genomic analysis of spontaneous intracerebral haemorrhage. Alzheimer’s Research UK Pilot project grant £50,000 (co-PI with Prof Henry Houlden).

2017 Exome sequencing of intracerebral haemorrhage Dunhill Medical Trust ~£50k (co-PI)

2017 Act-VaD. £1.1m Stroke Associaiton and Alzheimer’s Research (co-app)

2017 MRC-KHIDI UK-Korea Dementia Forum (co-app)

2017 Early versus Late AnticoagulatioN for acute cardieombolic stroke (ELAN). TSA £150k (co-app)

2017 Tenecteplase in Wake-up Ischaemic Stroke Trial (TWIST). BHF £150k (co-PI)

2017 Optimal timing of anticoagulation after ischaemic stroke due to atrial fibrillation (OPTIMAS). BHF £2.05m (CI)

2018 Stroke genetics: genotyping, analysis and developing a genomic resource. NIHR BRC £95,000 (Co-CI with Prof Henry Houlden)

SELECTED RELEVANT RECENT PUBLICATIONS (H index 53 [Google Scholar]; >200 peer-reviewed publications)

• Gregoire SM, Chaudhary UJ, Brown MM,…..Werring DJ. The Microbleed Anatomical Rating Scale (MARS): reliability of a tool to map brain microbleeds.Neurology. 2009;73(21):1759-66.

• Gregoire SM, Charidimou A, Gadapa N,……Werring DJ. Acute ischaemic brain lesions in intracerebral haemorrhage. Brain 2011; 134(Pt 8):2376-86.

• Charidimou A, Peeters A, Fox Z,……Werring DJ. Spectrum of transient focal neurological episodes in cerebral amyloid angiopathy: multicentre magnetic resonance imaging cohort study and meta-analysis. Stroke. 2012 Sep;43(9):2324-30.

• Gregoire SM, Scheffler G, Jäger HR,……Werring DJ. Strictly Lobar Microbleeds Are Associated With Executive Impairment in Ischemic Stroke. Stroke. May;44(5):1267-72.2013.

• Charidimou A, Jaunmuktane Z, Baron JC, Burnell M, Varlet P, Peeters A, Xuereb J, Jäger R, Brandner S, Werring DJ. White matter perivascular spaces: An MRI marker in pathology-proven cerebral amyloid angiopathy? Neurology. 2014 Jan7;82(1):57-62.

• Charidimou A, Jäger RH, Fox Z, Peeters A, Vandermeeren Y, Laloux P, Baron JC, Werring DJ. Prevalence and mechanisms of cortical superficial siderosis in cerebral amyloid angiopathy. Neurology. 2013 Aug 13;81(7):626-32.

• Greenberg SM, Al-Shahi Salman R, van Biessels GJ,……,Werring DJ. Outcome Markers for Clinical Trials in Cerebral Amyloid Angiopathy. Lancet Neurology 2014; 13(4):419-28.

• Wilson D, Charidimou A, Shakeshaft C, ……, Werring DJ; CROMIS-2 collaborators. Volume and functional outcome of intracerebral hemorrhage according to oral anticoagulant type. Neurology. 2016 Jan 26;86(4):360-6. doi: 10.1212/WNL.0000000000002310. Epub 2015 Dec 30. PubMed PMID: 26718576; PubMed Central PMCID: PMC4776084.

• Wilson D, Charidimou A, Ambler G,……, Werring DJ. Recurrent stroke risk and cerebral microbleed burden in ischemic stroke and TIA: A meta-analysis. Neurology. 2016 Sep 2. pii: 10.1212/WNL.0000000000003183. [Epub ahead of print] PubMed PMID: 27590288.

• Wilson D, Werring DJ. Antithrombotic therapy in patients with cerebral microbleeds. Curr Opin Neurol. 2017 Feb;30(1):38-47. doi: 10.1097/WCO.0000000000000411. PubMed PMID: 27898582.

• Kongbunkiat K, Wilson D, Kasemsap N, Tiamkao S, Jichi F, Palumbo V, Hill MD, Buchan AM, Jung S, Mattle HP, Henninger N, Werring DJ. Leukoaraiosis, intracerebral hemorrhage, and functional outcome after acute stroke thrombolysis. Neurology. 2017 Feb 14;88(7):638-645.

• Wilson D, Hostettler IC, Ambler G, Banerjee G, Jäger HR, Werring DJ. Convexity subarachnoid haemorrhage has a high risk of intracerebral haemorrhage in suspected cerebral amyloid angiopathy. J Neurol. 2017 Feb 2. doi: 10.1007/s00415-017-8398-y. [Epub ahead of print] Erratum in: J Neurol. 2017 Feb 27. PubMed PMID: 28154972.

• Wilson D, Seiffge DJ, Traenka C,……,Werring DJ. Outcome of intracerebral hemorrhage associated with different oral anticoagulants. Neurology. 2017 Apr 5. pii: 10.1212/WNL.0000000000003886. PubMed PMID: 28381513.

• Banerjee G, Wilson D, Ambler G,……Werring DJ; CROMIS-2 Collaborators. Cognitive Impairment Before Intracerebral Hemorrhage Is Associated With Cerebral Amyloid Angiopathy. Stroke. 2018 Jan;49(1):40-45. doi: 10.1161/STROKEAHA.117.019409. Epub 2017 Dec 15. PubMed PMID: 29247143.

• Banerjee G, Carare R, Cordonnier C,……Werring DJ. The increasing impact of cerebral amyloid angiopathy: essential new insights for clinical practice. J Neurol Neurosurg Psychiatry. 2017 Nov;88(11):982-994. doi: 10.1136/jnnp-2016-314697. Epub 2017 Aug 26. Review. PubMed PMID: 28844070; PubMed Central PMCID: PMC5740546.

• Wilson D, Ambler G, Shakeshaft C,……Werring DJ; CROMIS-2 collaborators. Cerebral microbleeds and intracranial haemorrhage risk in patients anticoagulated for atrial fibrillation after acute ischaemic stroke or transient ischaemic attack (CROMIS-2): a multicentre observational cohort study. Lancet Neurol. 2018 Jun;17(6):539-547. doi: 10.1016/S1474-4422(18)30145-5. Epub 2018 May 16. PubMed PMID:29778365; PubMed Central PMCID: PMC5956310.

• Sprigg N, Flaherty K, Appleton JP, ……Werring D, Whynes D, Bath PM; TICH-2 Investigators. Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial. Lancet. 2018 May 26;391(10135):2107-2115. doi: 10.1016/S0140-6736(18)31033-X. Epub 2018 May 16. PubMed PMID: 29778325; PubMed Central PMCID: PMC5976950.

• Banerjee G, Stone SP, Werring DJ. Posterior circulation ischaemic stroke. BMJ. 2018 Apr 19;361:k1185. doi: 10.1136/bmj.k1185. PubMed PMID: 29674391.