Lea T. Grinberg is a neuropathologist with an interest in brain aging and associated disorders. She is an associate professor of neurology and pathology at the University of California, San Francisco, where She directs the Human Validation Core for the National Institutes of Health-funded Center Without Walls for Tau Biology and Co-directs the Neurodegenerative disease brain bank. She is also an affiliated professor of pathology at the University of Sao Paulo, Brazil. Grinberg’s contributions to the field of dementia include: identifying brainstem nuclei as the earliest structures affected in Alzheimer’s disease and translating these findings to diagnostic and treatment development; using high-resolution histology and sophisticated computing tools to validate multimodal neuroimaging findings; and participating in several international neuropathological consortia to establish neuropathological criteria for neurodegenerative diseases and vascular dementia.