mark braschinsky, MD, PhD
HOBUSERAUA 72, Tartu 51011. TEl (+372)5585711
e-mail: mark.braschinsky@kliinikum.ee
education
2003 – 2010
Tartu University – Faculty of Medicine, PhD program (neurology)
2002 – 2006
Tartu University – Faculty of Medicine, postgraduate neurological residency
1999 – 2000
Tartu University – Faculty of Medicine, internship
1993 – 1999
Tartu University – Faculty of Medicine
1983 – 1993
Tallinn 48. School – chemistry-biology special
experience
2013 – present tim
Tartu University Neurology Clinic
Senior researcher
2006 – 2013
Tartu University Neurology Clinic
Scientific Fellow
2006 – present time
Tartu University Clinics, Neurology Clinic, dept. of neurology
neurologist (2014 – present time: senior teaching physician)
September 2002 – March 2006
Tartu University Clinics, Neurology Clinic
Resident
August 2000 – July 2002
West-Tallinn’s Central Hospital, Centre of Comprehensive Care of Multiple Sclerosis, Neurodegenerative Disorders and Chronic Pain
MD
August 1999 – June 2000
Tartu University Clinics
Internship-doctor
June 1996 – February 1999
Tartu University Clinics
ER nurse
teaching experience
January 2011 – present time
Centre for Continuing Medical Education, University of Tartu, E-medicine project for neurologists (curator, lecturer).
September 2008 – present time
Centre for Continuing Medical Education, University of Tartu, E-course “Primary headaches” (curator, lecturer).
September 2003 – present time
Tartu University, Faculty of Medicine (lecturer).
November 2002 – Detsember 2010
Centre for Continuing Medical Education, University of Tartu, Telemedicine project (curator, lecturer).
November 2002 – present time
Centre for Continuing Medical Education, University of Tartu (lecturer).
scientific work, publications, investigations, presentations
2019
Toom K, Raidvee A, Allas KH, Floria E, Juhkami K, Klimušev G, Leping M, Liidemann M, Milovidov A, Liivak K, Paiste S, Paju G, Uhs K, Vaikjärv M, Veetõusme K, Välja P, Braschinsky M. The prevalence of primary headache disorders in the adult population of Estonia. Cephalalgia 2019 Feb 11:333102419829909. doi: 10.1177/0333102419829909.
2018
Amin FM, Aristeidou S, Baraldi C, Czapinska-Ciepiela EK, Ariadni DD, Di Lenola D, Fenech C, Kampouris K, Karagiorgis G, Braschinsky M, Linde M. The association between migraine and physical exercise. J Headache Pain 2018 Sep 10;19(1):83. doi: 10.1186/s10194-018-0902-y.
Braschinsky M, Haldre S, Kals M, Arge M, Saar B, Niibek M, Katsarava Z, Steiner TJ. Structured education to improve primary-care management of headache: how long do the benefits last? A follow-up observational study. Eur J Neurol 2018 Mar;25(3):497-502.
Steiner TJ, Lipton RB, Lifting The Burden: The Global Campaign against Headache: Al Jumah M, Al-Khathami A, Allena M, Andrée C, Ayzenberg I, Braschinsky M, Gil-Gouveia R, Gökmen G, Gururaj G, Herekar A, Katsarava Z, Kissani N, Kulkarni G, Lainez M, Lampl C, Lantéri-Minet M, Linde M, Luvsannorov O, Manandhar K, Mbewe E, Quispe G, Rao G, Rastenytė D, Risal A, de la Torre ER, Schramm S, Selekler M, Stokes H, Stokes Brackett AC, Stovner LJ, Tassorelli C, Tekle-Haimanot R, Vriezen P, Yu SY, Zebenigus M. The Headache-Attributed Lost Time (HALT) Indices: measures of burden for clinical management and population-based research. J Headache Pain 2018 Feb 2;19(1):12. doi: 10.1186/s10194-018-0837-3.
Braschinsky M, Brin V, Toom K. Hormonaalne kontratseptsioon ja isheemilise insuldi risk migreeniga naistel. Eesti Arst 2018; 97(1):40–41.
Brin V, Toom K, Braschinsky M. Kroonilise migreeni diagnostika ja ravi. Eesti Arst 2018; 97(3):132–136.
Braschinsky M. Erenumab – uus migreeni profülaktiline ravivõimalus. Eesti Arst 2018; 97(6):333.
2017
Saar S, RinkenS, Mändul M, Braschinsky M. Kiirabi poolt migreenina käsitletud peavaluga patsiendid ja nende ravi. Eesti Arst 2017; 96(4):207–212.
Braschinsky M. Lasmiditaan – kas uus ravim migreeni hooraviks? Eesti Arst 2017; 96(4):239.
Avi A, Vetkas A, Asser A, Braschinsky M, Asser T. Kolmiknärvineuralgiaga patsientide operatsioonijärgse elukvaliteedi muutuse hindamine. Eesti Arst 2017; 96(6):319–325.
2016
Braschinsky M, Raidvee A, Sabre L, Zmachinskaja N, Zukovskaja O, Karask A, Saar B, Rakitin A. 3D cinema and headache: The First evidential relation and analysis of involved Factors. Front Neurol 2016 2016 Mar 23;7:30. doi: 10.3389/fneur.2016.00030.
Braschinsky M, Haldre S, Kals M, Ioofik A, Kivisild A, Korjas J, Koljal S, Katsarava Z, Steiner TJ. Structured education can improve primary-care management of headache: the first empirical evidence from a controlled interventional study. J Headache Pain Dec;17(1):24.
Schramm S, Uluduz D, Gouveia RG, Jensen R, Siva A, Uygunoglu U, Gvantsa G, Maka M, Braschinsky M, Filatova E, Skorobogatykh K, Osipova V, Azimova J, Straube A, Eren OE, Martelletti P, De Angelis V, Negro A, Linde M, Hagen K, Radojicic A, Zidverc-Trajkovic, Podgorac A, Paemeleire K, De Pue A, Lampl C, Steiner TJ, Katsarava Z. Headache service quality: Evaluation of quality indicators in 14 specialist-care centres. J Headache Pain. 2016 Dec;17(1):111.
Toom K, Laud T, Raidvee A, Braschinsky M. Promising Online Tool for Headache Epidemiology: The PRILEVEL Pilot Study. J Neurol Neurosurg 3(2): 126.
Sabre L, Rugo M, Asser T, Kõrv J, Braschinsky M. Headaches after traumatic spinal cord injury in Estonia. Cephalalgia 2016 Apr;36(5):403-12.
Sabre L, Braschinsky M, Taba P. Neurosyphilis as a great imitator: a case report. BMC Res Notes 2016 Jul 28;9:372.
Brin V, Toom K, Braschinsky M. Migreeni hooravi Eestis vajab korrastamist. Eesti Arst 2016; 95(9):605–609.
Anderson K, Pärt M, Kals M, Haldre S, Vija V, Braschinsky M. Migreeniga inimeste elukvaliteet ning selle hindamine. Eesti Arst 2016;95(3):155–161.
2015
Toom K, Laud T, Raidvee A, Braschinsky M. First online questionnaire for headache epidemiology: the PRILEVEL pilot study. Proc Latvian Acad Sci 2015;69(5):A22.
Toom K, Laud T, Braschinsky M. One questionnaire to diagnose most of the primary headaches: the PRILEVEL pilot study. Cephalalgia 2015; 35(65):154-5.
Mitsikostas D, Ashina M, Craven A, Diener HC, Goadsby PJ, Ferrari MD, Lampl C, Paemeleire K, Pascual J, Siva A, Olesen J, Osipova V, Martelletti P; EHF committee: Bendtsen, L, Bicakci, S, Braschinsky, M, Brossner, G, Constantinidis, T, Costa, C, Edvinsson, L, Freimane, A, Gantenbein, A, Gouveia, RG, Groseva, V, Hristova, S, Karli, N, Latysheva, N, Ljubisavljevic, S, Logina, I, Milanov, I, Obelleniene, D, Palavra, F, Parreira, E, Riederer, F, Sacco, S, Schytz, H, Sergeev, A, Steinber, A, Toom, K, Vikelis, M, Zebenholzer, K, Zidvec-Trajkovic, J. European headache federation consensus on technical investigation for primary headache disorders. J Headache Pain. 2015 Dec;17(1):5. doi: 10.1186/s10194-016-0596-y.
Polydefkis M, Arezzo J, Nash M, Bril V, Shaibani A, Gordon RJ, Bradshaw KL, Junor RW; Ranirestat Study Group. Safety and efficacy of ranirestat in patients with mild-to-moderate diabetic sensorimotor polyneuropathy. J Peripher Nerv Syst 2015 Dec;20(4):363-71.
Pärt M, Anderson K, Kals M, Braschinsky M. Which test to use to measure migraine’s burden and influence on everyday life? Cephalalgia 2015; 35(65):165-6.
Avi A, Vetkas A, Asser A, Braschinsky M, Asser T. Evaluation of postoperative change in quality of life in patients with trigeminal neuralgia. Cephalalgia 2015; 35(65):166.
Brin V, Braschinsky M. Tugev äkkpeavalu ja pearinglus kui vertebrobasilaarsüsteemi ajuinfarkti esmastunnused. Eesti Arst 2015;94(4):227–9.
Braschinsky M. Harry Potteri peavalu – kas vajame uut klassifikatsiooni? Eesti Arst 2015;94(4):255.
2014
Braschinsky M. The global epidemiology of hereditary ataxia and spastic paraplegia: what are the messages? Neuroepidemiology. 2014;42(3):184-5.
Vahi P, Kals M, Kõiv L, Braschinsky M. Preoperative corticosteroid injections are associated with worse long-term outcome of surgical carpal tunnel release. Acta Orthop 2014 Feb;85(1):102-6.
Sabre L, Rugo M, Kõrv J, Braschinsky M. Headaches after traumatic spinal cord injury. The Journal of Headache and Pain 2014;15(1),10.
Braschinsky M, Rakitin A, Zmachinskaja N, Zukovskaja O, Saar B, Karask A, Sabre L. 3D-cinema and headache: preliminary results of a prospective cross-sectional study. The Journal of Headache and Pain 2014;15(1),15.
Braschinsky M, Haldre S, Kals M, Iofik A, Kivisild A, Korjas J, Koljal S, Katsarava Z, Steiner TJ. Demonstrational project: to develop, implement and test an educational model for better headache-related primary health care. The Journal of Headache and Pain 2014;15(1),31.
Vahi P, Kals M, Kõiv L, Braschinsky M. Operatsiooni eel tehtud kortikosteroidsüsted on seotud karpaalkanali sündroomi kirurgilise ravi halvema kaugtulemusega. Eesti Arst 2014; 93(6):324–329.
Vilisaar J, Braschinsky M, Sinisalu V. Kroonilise valusündroomi praktiline käsitlus. Eesti Arst 2014; 93(5):269–274.
Braschinsky M. Valu. Eesti Arst 2014; 93(1):51–52.
2013
Sabre L, Braschinsky M. Vestibulaarne migreen. Eesti Arst 2013; 92(5):279–282.
2012
Tomberg T, Braschinsky M, Rannikmäe K, Kepler J, Kepler K, Kõrv J, Linnamägi Ü, Asser T. Functional MRI of the cortical sensorimotor system in patients with hereditary spastic paraplegia. Spinal cord. 2012 Dec;50(12):885-90.
Braschinsky M. Medication overuse headache in Estonia. 7th Baltic Congress of Neurology. Tartu, Estonia. May 9-12, 2012. Oral presentation.
Braschinsky M. Can functional MRI be used as a preclinical marker in hereditary spastic paraplegia? 7th Baltic Congress of Neurology. Tartu, Estonia. May 9-12, 2012. Oral presentation.
2011
Braschinsky M. Esimene Baltimaade migreenisümpoosion. Eesti Arst 2011;90(10):485-485.
Sabre L., Õunapuu A., Braschinsky M. Reversiibel tserebraalne vasokonstriktsiooni sündroom. Ülevaade ja haigusjuhu kirjeldus. Eesti Arst 2011;90(11):529-533.
Braschinsky M. Migreeni ravi. Lege Artis 2011;7(108):13-15.
Braschinsky M. Primaarne peavalu ja väsimuse põhjused: kas naistel on erikoht? Lege Artis 2011;4(105):10-12.
Ling H, Braschinsky M, Taba P,Lüüs SM, Doherty K, Hotter A, Poewe W, Lees A. Decades of Delayed Diagnosis in 4 Levodopa-Responsive Young-Onset Monogenetic Parkinsonism Patients. Movement Disorders. 2011 DOI: 10.1002/mds.23563.
Braschinsky M, Rannikmäe K, Krikmann U, Lüüs SM, Raidvee A, Gross-Paju K, Haldre S. Health-related quality of life in patients with hereditary spastic paraplegia in Estonia. Spinal Cord. 2011;26(7):1337-40.
Ennok M, Sabre L, Braschinsky M. Neuropsychological features in advanced dementia due to neurosyphilis: A case report. The 2011 International Neuropsychological Society Mid-Year Meeting, Auckland, Uus-Meremaa. 06.-09.07.2011.
2010
Kaitstud doktoritöö “Hereditaarse spastilise parapleegia epidemioloogia Eestis, antud haigusega inimeste elukvaliteet ning geen-analüüsi juurutamine närvihaiguste diagnostikas”.
Braschinsky M, Zopp I, Kals M, Haldre S, Gross-Paju K. Bladder Dysfunction in Hereditary Spastic Paraplegia: What to Expect? J Neurol Neurosurg Psychiatry 2010;81:263-6.
Braschinsky M, Tamm R, Beetz C, Sachez-Ferrero E, Raukas E, Lüüs SM, Gross-Paju K, Boillot C, Canzian F, Metspalu A, Haldre S. Unique spectrum of SPAST variants in Estonian HSP patients: presence of benign missense changes but lack of exonic rearrangements. BMC Neurology 2010 doi:10.1186/1471-2377-10-17.
Braschinsky M, Rannikmäe K, Tamm R, Metspalu A, Gross-Paju K, Haldre S. Esimene hereditaarset spastilist parapleegiat süsteemselt käsitlenud uuring Eestis tõi esile originaalandmeid. Eesti Arst 2010
Braschinsky M, Tomberg T, Rannikmäe K, Kepler J, Kepler K, Kõrv J, Linnamägi Ü, Asser T. Sensomotoorse funktsiooni kortikaalne reorganistatsioon hereditaarse spastilise parapleegia korral. Tartu Ülikooli arstiteaduskonna aastapäeva teaduskonverents; 07.-08.10.2010, Tartu, Eesti. Poster.
Tomberg T, Brashinsky M, Rannikmäe K, Kepler J, Kepler K, Kõrv J, Linnamägi Ü, Asser T. Functional imaging of the cortical motor system in patients with hereditary spastic paraplegia. 14th European Federation of Neurological Societies Congress, 25-28.09.2010, Geneva, Switzerland. Poster.
Tomberg T, Braschinsky M, Rannikmäe K, Kepler J, Kepler K, Kõrv J, Linnamägi Ü, Asser T. Cortical reorganization of the sensorimotor function in patients with spinal cord degenerative disease. 3rd Baltic Congress of Radiology, 8-9.10.2010, Riga, Latvia. Poster.
2009
Braschinsky M, Lüüs S-M, Gross-Paju K, Haldre S. “The prevalence of hereditary spastic paraplegia and the occurence of SPG4 mutations in Estonia”. Neuroepidemiology 2009, 32:89-93.
Braschinsky M, Parts K, Maamägi H, Gross-Paju K, Haldre S. Functional assessment of lower extremities in hereditary spastic paraplegia. Arch Phys Med Rehabil. 2009 Nov;90(11):1887-90.
Vahter L, Braschinsky M, Haldre S, Gross-Paju K. The prevalence of depression in hereditary spasatic paraplegia. Clin Rehabil 2009 Sep;23(9):857-61.
Brin V, Braschinsky M. Primaarsete peavalude krooniliseks muutumine ja sellega seotud probleemid. Eesti Arst 2009; 88(2):104−108
Rannikmäe K, Braschinsky M, Liik M, Linnamägi Ü. Transitoorne epileptiline amneesia. Eesti Arst 2009; 88(2):125−130.
Braschinsky M. NMDA retseptorsüsteemid närvihaiguste korral. Eesti Arst 2009; 88(6):433−436.
Tamm R, Braschinsky M, Raukas E, Lüüs S-M, Gross-Paju K, Boillot C, Canzian F, Metspalu A, Haldre S. SPG4 genetic heterogenity in Estonian patients with hereditary spastic paraplegia. The Baltic Summer School. Germany, Kiel, 5-18 September 2009. Poster.
Rannikmäe K, Braschinsky M, Kepler K, Tomberg T. Is a fMRI study helpful for the differential diagnosis of corticospinal tract infarction and unilateral motor conversion disorder? 13th Congress of the Eurpean Federation of Neurological Societies. Florence, Italy, 12-15 September 2009. Poster.
Vahter L, Braschinsky M, Haldre S, Gross-Paju K. The prevalence of cognitive dysfunction in the Estonian population of hereditary spastic paraplegia. Neuropsychological Society Midsummer meeting. Helsinki, Finland, 29-31 August 2009. Poster.
Braschinsky M, Lüüs S-M, Taba P. Genetic Parkinsonism: 10 years of natural history. 6th Baltic Congress of Neurology (BALCONE), Vilnius, Lithuania, 13-16 May 2009. Oral presentation.
2008
Linnamägi Ü, Braschinsky M, Sinisalu V. Aju ja armastus. Eesti Arst 2008;87(4):269-73.
Braschinsky M. Pearinglus ja tasakaaluhäired: tsentraalsed põhjused. Lege Artis 2008;8(76):5-7.
Linnamägi Ü, Braschinsky M, Saks K, Võrk E, Lääts T. Käsiraamat dementsete haigete hooldajale. Tallinn: Eesti Alzheimeri Tõve Ühing, 2008.
2007
Braschinsky M, Vibo R, Rallmann K, Asser A, Tomberg T. Aju venoossete siinuste tromboos. Eesti Arst 2007; 86(12):897-902.
Braschinsky M, Raukas E, Tamm R, Lüüs S-M, Gross-Paju K, Boillot C, Canzian F, Metspalu A, Haldre S. Hereditary spastic paraplegia in Estonia: SPG4 mutations and phenotypic description. 11th Congress of the European Federation of Neurological Societies – EFNS. Brussels, Belgium. August 25-28, 2007. Poster.
Braschinsky M. Pearinglus – fookuses vestibulaarne düsfunktsioon. Lege Artis 2007;7(64):15-8.
Brin V, Braschinsky M, Haldre S. Tugeva äkkpeavalu diferentsiaaldiagnoos. Eesti Arst 2007; 86(4):262-5.
Braschinsky M, Areda T, Linnamägi Ü. Tartu Ülikooli närvikliinikus töötamine suurendab kaksikute sündimise riski . Eesti Arst 2007; 86(4):235-8.
Linnamägi Ü, Braschinsky M, Tikk A. Fibromüalgia. Eesti Arst 2007; 86(3):201-6.
Vähi M, Kirsimägi Ü, Braschinsky M. Alzheimeri tõve ravi memantiiniga Eestis: farmakoökonoomiline hindamine . Eesti Arst 2007; 86(2):94-9.
2006
Braschinsky M. Nimesuliidi kasutamine peavalu ravis. Perearst 2006; 7(20):20-1.
Rakitin A, Kompus K, Braschinsky M, Nurm M. Wernicke-Korsakovi sündroom ja memantiin. Eesti Arst 2006; 85(11):766-71.
Braschinsky M, Lüüs S-M, Gross-Paju K, Haldre S. Hereditary spastic paraplegia in Estonia. 10th Congress of the European Federation of Neurological Societies – EFNS. Glasgow, Great Britain, 2-5 September, 2006. Poster.
Braschinsky M, Lüüs S-M, Gross-Paju K, Haldre S. Hereditary spastic paraplegia in Estonia. 5th Baltic Congress of Neurology (BALCONE), Riga, Latvia, 1.-3. June 2006. Oral presentation.
2005
Linnamägi Ü., Braschinsky M. Alzheimeri tõve ravi mittekolinergiliste ravimitega – hetkeseis ja perspektiivid. Eesti Arst 2005; 84(11):781-6.
Braschinsky M. Mälu ja ravimid. Lege Artis lisaväljaanne „Mälu” September 2005:16-20.
2004
Braschinsky M, Haldre S, Sema L, Maamägi H, Parts K, Lüüs S-M, Gross-Paju K. Hereditary spastic paraplegia in Estonia – preliminary results of the study. 8th Congress of the European Federation of Neurological Societies – EFNS. Paris, France, 4-7 September, 2004. Poster.
2003
Braschinsky M.Possible CNS tuberculoma. Salzburg Medical Seminars International, neurology and neurosurgery. Salzburg, Austria, 7-13 February 2003. Suuline ettekanne.
2002
Braschinsky M, Gross-Paju K. Acute leukemia and climax as possible complications of Mitoxantrone treatment. 2nd international MS week: A World View. Chicago, Illinois, USA, 6-9 June 2002. Poster.
Braschinsky M, Porosaar M, Gross-Paju K. Multisüsteemne atroofia – täpsem diagnoosi võimalus. Eesti Arst 2002;81(7):427-30.
Teder-Braschinsky A, Braschinsky M, Mets H, Gross-Paju K. Sclerosis multiplex ja rasedus. Eesti Arst 2002;12:812-5.
2001
Braschinsky M, Raudmäe K, Gross-Paju K. The rare complication of mitoxantrone treatment in person with MS. International Journal of MS Care 2001;3(3):2.
Braschinsky M, Raudmäe K, Gross-Paju K. The rare complication of mitoxantrone treatment in person with Multiple Sclerosis. 7th Annual Meeting of R.I.M.S. (Rehabilitation in Multiple Sclerosis), Copenhagen, Denmark, 16-19 May 2001. Poster, Oral presentation.
Gross-Paju K, Braschinsky M, Zopp I. Bladder dysfunction and its management in Multiple Sclerosis. Neurologijos seminarai 2001; 1-2(11-12): 79-84.
1998
Braschinsky M. Atoopiline dermatiit. Tartu Ülikooli Kliinikumi Lastehaigla Üliõpilaste Teaduskonverents. Oral presentation (awarded: 1.prize).
reviewer for an international cited journals
Cephalalgia
Neuroepidemiology
Synapce
BMC Neurology
European Archives of Psychiatry and Clinical Neuroscience
European Urology
social activity
2018 – present time International Headache Society. Board Member.
2016 – present time European Headache Federation. Board Member.
2015 – present time European Headache Federation. Member.
2014 – present time European Academy of Neurology: Headache Scientific Panel. Member.
2011 – present time Estonian Headache Society. Founder. President.
2009 – present time Estonian Pain Society. Board member.
2009 – present time International Headache Society. Affiliate member. Advisory board member.
2007 – present time Central and Eastern Europe Against Migraine. Board member.
2009 – present time European Academy of Neurology (former EFNS). Member.
2006 – present time Estonian Society of Neurologists and Neurosurgeons. Member.
clinical trials, scientific projects
2017 – 2019 Efficacy of L-cysteine in Prevention of Headache Attacks in Migraine Patients. Randomized intervention trial with a medical device (AcetiumTMCapsules). Principal investigator.
2014 – 2016 A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of BIIB074 in Subjects With Neuropathic Pain From Lumbosacral Radiculopathy. Principal investigator.
2014 – 2016 Opiods’ induced constipation in chronic pain patients. Principal investigator.
2012 – 2013 Trigeminal neuralgia. Principal investigator.
2011 – 2011 Long-term effects of local treatment of carpal tunnel syndrome. Principal Investigator.
2009 – 2014 Spinal cord injuries in Estonia. Investigator.
2009 – 2012 Diabetic polyneuropathy. Principal Investigator.
2007 – 2013 Molecular and psychosocial factors influencing the prognosis of brain disorders. Investigator.
2004 – 2009 Alzheimer’s disease (2 trials). Investigator.
2006– 2008 Multiple sclerosis (3 trials). Investigator.
Gcp and additional professional training
GCP training. International, Quintiles.
October 2007, 2018
GCP training. Tartu, Estonia.
June 2006
GCP training. Madrid, Spain.
May 2006
GCP training. Nice, France.
February 2006
GCP training. London, UK.
Januar y- February 2006
„Clinical attachment programme”. NIH „Queen Square” Hospital, London, UK.
June 2005 – December 2006
„Teaching Evidence-Based Neurology in Europe: Epilepsy, Multiple sclerosis, Parkinson’s disease, Stroke”. London, UK; Madrid, Spain; Lissabon, Portugal; Perugia, Italy.
languages
Estonian, Russian, English